Acidente vascular encefálico hemorrágico em pacientes com infecção por COVID-19
uma revisão sistemática de literatura
DOI:
https://doi.org/10.47822/bn.v12i2.688Palavras-chave:
Acidente Vascular Encefálico Hemorrágico, Covid-19, Manifestações Neurológicas, Distúrbios CerebrovascularesResumo
Objetivo: analisar, baseado na literatura, os impactos da pandemia e da infecção pela COVID-19 na ocorrência de eventos cerebrovasculares hemorrágicos. Materiais e Métodos: trata-se de uma revisão sistemática da literatura, selecionando artigos em inglês, português e espanhol publicados entre 2020 e 2022, disponíveis nas bases de dados Biblioteca Virtual em Saúde, LILACS, SciELO e PubMed, usando os descritores: “Hemorrhagic Stroke or Intracranial hemorrhage”, “Covid-19 or Sars-CoV-2” AND “Nervous system or Neurologic Manifestations” AND “Cerebrovascular Disorders”. A inclusão das publicações foi baseada na análise dos títulos, resumos e palavras-chave. Foram excluídos resumos, opiniões de especialistas, editoriais e relatos de casos. Resultados: foram selecionados 12 artigos de 115 publicações. Os estudos mostraram um aumento na ocorrência de acidente vascular encefálico hemorrágico em paciente infectados pela COVID-19, principalmente naqueles que apresentavam comorbidades. Acometeu predominantemente negros e latinos e pacientes de meia idade. A hemorragia intracraniana foi o subtipo mais comum. A gravidade do quadro, a redução da mobilidade e o medo de contrair a infecção afetaram diretamente a abordagem diagnóstica e terapêutica de tais pacientes. Conclusão: pacientes contaminados pelo SARS-CoV-2 apresentaram maior risco de hemorragia cerebral, principalmente aqueles que já apresentavam doença cerebrovascular prévia, além de elevada morbimortalidade.
Referências
Brito WGF, Silva JPDO. Impactos neuropatológicos do COVID-19. Braz J Health Review. 2020;3(3):4227-35. Available from: https://doi.org/10.34119/bjhrv3n3-026
Chu H, Chan JF, Yuen TT, Shuai H, Yuan S, Wang Y et al. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe, 2020;1(1):e14-e23. Available from:
https://doi.org/10.1016/S2666-5247(20)30004-5
Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;87:18-22. Available from: https://doi.org/10.1016/j.bbi.2020.03.031
Gutiérrez-Ortiz C, Méndez A, Rodrigo-Rey S, Pedro-Murilo ES, Bermejo-Guerrero L, Gordo-Mañas R et al. Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020;95(5):e601-e605. Available from: https://doi.org/10.1212/WNL.0000000000009619
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42. Available from: https://doi.org/10.1001/jama.2020.2648
Sahu KK, Lal A, Mishra AK. Latest updates on COVID-2019: A changing paradigm shift. J Med Virol. 2020. Available from: https://doi.org/10.1002/jmv.25760
Mishra AK, Sahu KK, Lal A and Sargent J. Patterns of heart injury in COVID-19 and relation to outcome. J Med Virol. 2020. Available from: https://doi.org/10.1002/jmv.25847
Accorsi DX, dos Santos IAM, Accorsi JX, Bohac S, Chin CM. COVID-19 e o Sistema Nervoso Central. Ulakes J Med [Internet]. 2019 [Acesso: 20 Dez 2022]; 1:81-7. Disponível em: http://www.medimay.sld.cu/index.php/rcmh/article/view/1488
Mao L, Wang M, Chen S, He Q, Chang J, Hong C et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. SSRN Journal. 2020. Available from: https://doi.org/10.1001/jamaneurol.2020.1127
Li Y, Wang M, Zhou Y, Chang J, Xian Y, Mao L et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol, 2020;5(3):279-84. Available from: https://doi.org/10.1136/svn-2020-000431
Rendón AL, Méndez NH. Covid-19: Fisiopatología y Complicaciones Cerebrovasculares. Ictus, 2021;2(3):e05092102018-e05092102018. Available from: https://doi.org/10.5281/zenodo.5454665
Wang H, Tang X, Fan H, Luo Y, Song Y, Xu Y et al. Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients. Aging (Albany NY). 2020;12(11):10022. Available from: https://doi.org/10.18632/aging.103335
Del Busto JEB. Consideraciones a tener en cuenta en la enfermedad cerebrovascular como problema de salud. Medimay [Internet]. 2019 [citado: 26 Dic 2022]; 26(3):380-2. Disponible en: http://www.medimay.sld.cu/index.php/rcmh/article/view/1488
Centre for Evidence-Based Medicine. Oxford Center for Evidence Based Medicine [Internet]. Oxford: CEBM; 2013 [cited 2023 Mar 13]. Available from: http://www.cebm.net/index.aspx?o=5653
Kurtz P, Bastos LSL, Zampieri FG, de Freitas GR, Bozza FA, Soares M et al. Trends in Intensive Care Admissions and Outcomes of Stroke Patients Over 10 Years in Brazil: Impact of the COVID-19 Pandemic. Chest. 2022 Nov 5:S0012-3692(22)04049-1. Available from: https://doi.org/10.1016/j.chest.2022.10.033
Ramachandran D, George GB, Panicker P, Aravind R, Suresh MK, Iype T. COVID-19 e Stroke Trends in A Tertiary Care Center from South India -Our Monsoon Experience. Neurol Índia 2022;70:1942-6. Available from: https://doi.org/10.4103/0028-3886.359188
Ramos AD, Koyfman F, Byrns K, Wu A, Yasen J, Elreda L et al. Characterization of Hemorrhagic and Ischemic Stroke in a Diverse Cohort of COVID-19 Patients. Neurohospitalist. 2021 Oct;11(4):295-302. Available from: https://doi.org/10.1177/1941874421990545
Nia AM, Srinivasan VM, Lall RR, Kan P. COVID-19 and Stroke Recurrence by Subtypes: A Propensity-Score Matched Analyses of Stroke Subtypes in 44,994 Patients. J Stroke Cerebrovasc Dis. 2022;31(8):106591. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106591
Altschul DJ, Unda SR, de La Garza Ramos R, Zampolin R, Benton J, Holland R et al. Hemorrhagic presentations of COVID-19: Risk factors for mortality. Clin Neurol Neurosurg. 2020;198:106112. Available from: https://doi.org/10.1016/j.clineuro.2020.106112
Wang H, Tang X, Fan H, Luo Y, Song Y, Xu Y et al. Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients. Aging (Albany NY). 2020 Jun 11;12(11):10022-10034. Available from: https://doi.org/10.18632/aging.103335
Shoskes A, Huang M, Gedansky A, Hassett C, Buletko AB, Duggal A et al. MRI of Cerebrovascular Injury Associated With COVID-19 and Non-COVID-19 Acute Respiratory Distress Syndrome: A Matched Case-Control Study. Crit Care Med. 2022;50(11):1638-43. Available from: https://doi.org/10.1097/CCM.0000000000005658
Castro PNPD, Chagas LA, Wajnberg E, Santos R, Cougo P, Machado DC. Vascular Spectrum of Imaging Findings in COVID-19: Ischemic, Hemorrhagic, and Thromboembolic Complications. Int J Cardiovasc Sci, 2021;35(4):546-56. Available from: https://doi.org/10.1148/rg.220059
Lazcano U, Cuadrado-Godia E, Grau M, Subirana I, Martínez-Carbonell E, Boher-Massaguer M et al. Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study. Stroke, 2022;53(4):1276-84. Available from: https://doi.org/10.1161/STROKEAHA.121.036257
Mishra S, Choueka M, Wang Q, Hu C, Visone S, Silver M et al. Intracranial Hemorrhage in COVID-19 Patients. J Stroke Cerebrovasc Dis. 2021 Apr;30(4):105603. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105603
Shkoukani A, Srinath A, Stadnik A, Girard R, Shenkar R, Sheline A et al. COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation. J Stroke Cerebrovasc Dis. 2021;30(11):106101. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106101
Siegler JE, Cardona P, Arenillas JF, Talavera B, Guillen AN, Chavarría-Miranda A et al. Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry. Int J Stroke. 2021;16(4):437-47. Available from: https://doi.org/10.1177/1747493020959216
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 Matheus Costa Leite, Marcelo José da Silva de Magalhães
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
